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Published on: March 6, 2018
Risk Factors for Hot Flashes Associated with Androgen Deprivation Therapy in Japanese Patients with Prostate Cancer
Momoko Sawada1, Ryo Inose2, Kosuke Okasho3
1Department of Pharmacy, Federation of National Public Service Personnel Mutual Aid Associations Hirakata Kohsai Hospital, Osaka, Japan.
JMA Journal
|June 10, 2026
Summary
Younger age increases hot flash risk in Japanese prostate cancer patients undergoing androgen deprivation therapy. Beta-blockers may reduce this side effect, improving patient quality of life.
Area of Science:
- Oncology
- Pharmacology
Background:
- Androgen deprivation therapy (ADT) is crucial for prostate cancer treatment.
- Hot flashes are a significant side effect of ADT, impacting patient quality of life.
- Limited research exists on ADT-related hot flash risk factors in Japanese populations, especially regarding comorbid conditions and medications.
Purpose of the Study:
- To identify risk factors for hot flashes in Japanese prostate cancer patients receiving ADT.
- To investigate the influence of concomitant medications on hot flash occurrence.
Main Methods:
- A single-center retrospective cohort study was conducted.
- 180 prostate cancer patients receiving luteinizing hormone-releasing hormone agonists or antagonists were analyzed.
- Multivariate logistic regression assessed associations between demographics, comorbidities, medications, and hot flash onset.
Main Results:
- 55.0% of patients experienced hot flashes.
- Younger age was significantly associated with an increased risk of hot flashes (OR 1.056, p=0.034).
- Concomitant atrial fibrillation (OR 0.257, p=0.038) and beta-blocker use (OR 0.265, p=0.021) were linked to a decreased risk.
Conclusions:
- Younger age is a key risk factor for ADT-induced hot flashes in Japanese prostate cancer patients.
- Beta-blockers show potential as a preventative or therapeutic option for managing hot flashes.
- Further research is warranted to confirm these findings and explore beta-blocker mechanisms in hot flash mitigation.
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