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Related Experiment Video

Updated: Jun 11, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer
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Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

Sublobar Resection in Stage I Non-Small Cell Lung Cancer With Lymphovascular Invasion.

Joshua R Brady1, Brittany Walker1, Jocelyn C Zajac1

  • 1Division of Cardiothoracic Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Annals of Thoracic Surgery Short Reports
|June 10, 2026
PubMed
Summary

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For stage I lung cancer with lymphovascular invasion (LVI), sublobar resection offers similar survival and recurrence outcomes compared to lobar resection. Completion lobectomy may not provide additional clinical benefit for these patients.

Area of Science:

  • Thoracic Surgery
  • Surgical Oncology
  • Pulmonary Medicine

Background:

  • Stage I lung cancer ≤2 cm is often treated with sublobar resection.
  • The benefit of sublobar resection in patients with lymphovascular invasion (LVI), a marker of aggressive disease, is uncertain.

Purpose of the Study:

  • To evaluate the impact of lymphovascular invasion (LVI) on outcomes in stage I non-small cell lung cancer (NSCLC) ≤2 cm treated with sublobar versus lobar resection.

Main Methods:

  • Retrospective cohort analysis of 245 patients with stage I NSCLC ≤2 cm from 2016-2022.
  • Comparison of baseline characteristics, overall survival, and cumulative recurrence between patients with and without LVI.
  • Kaplan-Meier method used for survival and recurrence analysis.

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Last Updated: Jun 11, 2026

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Main Results:

  • LVI was present in 18% of patients and associated with poorly differentiated grade and larger tumor size.
  • LVI-positive patients had significantly reduced overall survival and increased cumulative recurrence.
  • No significant difference in overall survival or recurrence was observed between sublobar and lobar resections in LVI-positive patients.

Conclusions:

  • Sublobar resection provides comparable survival and recurrence outcomes to lobar resection for stage I NSCLC ≤2 cm with LVI.
  • Completion lobectomy may not offer a significant clinical advantage in this specific patient group.