Seronegative Paraneoplastic Limbic Encephalitis in Non-Small Cell Lung Cancer: A Case of Neuropsychiatric Symptoms...

Paraneoplastic syndromes (PNS) are rare manifestations of particular malignancies. PNS symptoms have been postulated to be caused by hormonal secretion or immune cross-reactivity with the tumor. Although classically associated with small cell carcinoma, PNS have been reported across many cancers, including non-small cell carcinoma. We present an unusual case of a patient whose diagnosis of non-small cell carcinoma was discovered through a workup for new onset of neuropsychiatric symptoms that resolved within days after the resection of her primary cancer. Surgical resection of the underlying malignancy remains the fastest and most definitive treatment for paraneoplastic symptoms.