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Multicenter Randomized Trial to Prevent Pulmonary Vein Stump Thrombus After Left-Sided Anatomical Lung Resection
Aritoshi Hattori1, Kazuya Takamochi1, Keisuke Ariyoshi2
1Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Background:
Pulmonary vein stump thrombosis (PVST) is frequently detected on follow-up computed tomography in patients who have undergone left-sided anatomical pulmonary resection. In particular, a floating thrombus in the pulmonary vein stump has been identified as a potential cause of several postoperative systemic embolic complications, including cerebral infarction, highlighting the unmet need to improve postoperative outcomes in general thoracic surgery.
Methods:
This randomized trial aims to confirm the efficacy of postoperative heparin administration in preventing PVST and postoperative cerebral infarction, focusing exclusively on left-sided anatomical pulmonary resections. The primary end point is the frequency of PVST on contrast-enhanced computed tomography scans at postoperative day 5 ± 2. The secondary end point is the frequency of systemic thromboembolic events, including cerebral infarction. The study expects to enroll 250 patients from 26 institutions over 2.5 years.
Results:
The PV STUDY (Postoperative heparin administration to prevent pulmonary vein stump thrombus after left side anatomical pulmonary resection: Multicenter Randomized Phase II trial) has been open since October 2024, and the trial registration is now ongoing.
Conclusions:
The primary analysis is scheduled for spring 2027.
