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Advancements in Respiratory Syncytial Virus (RSV) Prevention and Treatment in Pediatrics

J Hunter Fly1, Jeremy S Stultz2, Lea S Eiland3

  • 1Department of Clinical Pharmacy and Translational Science (JHF), The University of Tennessee Health Science Center College of Pharmacy, Memphis, TN.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|June 10, 2026
PubMed

Insights

New RSV preventatives like nirsevimab and RSVpreF offer hope for reducing severe respiratory syncytial virus (RSV) infections in infants and children. This review evaluates these therapies, crucial for global child health.

Area of Science:

  • Pediatrics
  • Virology
  • Immunology

Background:

  • Respiratory syncytial virus (RSV) causes significant global morbidity and mortality, especially in young children.
  • Over 30 million lower respiratory infections and 100,000 deaths annually are linked to RSV in children under five.
  • Limited effective treatments necessitate a focus on prevention strategies.

Purpose of the Study:

  • To review and evaluate recently approved preventative therapies for RSV in pediatric populations.
  • To synthesize data on nirsevimab, RSVpreF, clesrovimab, and palivizumab.
  • To provide a comprehensive overview of RSV disease, including its epidemiology, diagnosis, and management.

Main Methods:

  • Literature review and data synthesis.
  • Evaluation of approved monoclonal antibodies and vaccines for RSV prevention.
  • Discussion of RSV virology, transmission, clinical presentation, and current treatment approaches.

Main Results:

  • Recently approved monoclonal antibodies and vaccines show potential to significantly reduce RSV disease burden.
  • Nirsevimab and RSVpreF are key preventative therapies discussed.
  • Existing treatments are limited, emphasizing the importance of preventative measures.

Conclusions:

  • Approved preventative therapies hold promise for altering the global impact of RSV on infants and children.
  • Continued evaluation of new treatment entities for RSV in pediatrics is ongoing.
  • Prevention remains the most critical strategy for managing RSV due to limited therapeutic options.

Keywords:
infantmonoclonal antibodiesneonatepediatricsrespiratory syncytial virus infectionsrespiratory syncytial virus vaccine

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