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Related Experiment Video

Updated: Jun 11, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

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Targeting Phantom Limb Pain with Cannabinoids in a Rat Model.

Anjalika Eeswara1, Kristin Perrucci1, Stanislava Jergova1

  • 1Department of Neurosurgery, Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL, USA.

Medical Cannabis and Cannabinoids
|June 10, 2026
PubMed
Summary
This summary is machine-generated.

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Cannabinoids like cannabidiol (CBD), β-caryophyllene (BCP), and THC show promise for phantom limb pain (PLP). Tailored cannabinoid treatments effectively reduced pain, with specific compounds showing benefits at different treatment stages.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Phantom limb pain (PLP) is a severe neuropathic condition with limited treatment options.
  • Cannabinoids (CBD, BCP, THC) possess analgesic and anti-inflammatory properties relevant to neuropathic pain.

Purpose of the Study:

  • To evaluate the efficacy of combined cannabinoids (CBD/BCP/THC) as preventive or delayed interventions for PLP in a rodent model.
  • To investigate the impact of cannabinoid treatments on pain behaviors, spinal cytokine levels, glial reactivity, and GABAergic signaling.

Main Methods:

  • A rodent model of PLP was established using sciatic nerve injury and inflammation.
  • Cannabinoid combinations (CBD/BCP/THC, CBD/BCP, THC) or vehicle were administered preemptively or after pain onset.
  • Pain behaviors, spinal cytokine profiles, glial activation, and GABAergic signaling were assessed over 72 days.
Keywords:
Beta-caryophylleneCannabidiolNeuropathic painPhantom limb painTetrahydrocannabinol

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Last Updated: Jun 11, 2026

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Main Results:

  • Preemptive THC or CBD/BCP significantly reduced PLP onset and severity.
  • Delayed treatment with CBD/BCP or CBD/BCP/THC was most effective in mitigating established PLP.
  • Pain relief correlated with restored spinal GABAergic inhibition and reduced neuroinflammation (decreased glial reactivity, anti-inflammatory cytokine shift).

Conclusions:

  • Cannabinoid interventions show significant therapeutic potential for PLP, effective in both early and delayed treatment paradigms.
  • THC may be more effective preemptively, while CBD and BCP show advantages in established pain.
  • Optimizing cannabinoid combinations and dosing strategies is crucial for maximizing analgesic effects in neuropathic pain.