Preliminary Estimates of New Invasive Cancers Diagnosed in 2023 in the United States

Incidence of new cancer cases is tracked by population-based cancer registries. Collecting complete information from initial diagnosis through first course of treatment can take up to 2 years. In June 2025, the United States (US) Centers for Disease Control and Prevention (CDC) released reports of cancer incidence for cases diagnosed through 2022, the most recent diagnosis year for which complete cancer incidence data were available. Having more timely data may be useful in planning cancer prevention and control efforts, and preliminary incidence estimates may help fill that gap.

We estimated preliminary rates and counts of new cancer cases in 2023 using reported US Cancer Statistics data for 2000 to 2019 and age-period-cohort models to account for changes in population size, age distribution, and cancer risk. Estimates were calculated for all cancers combined and 23 common cancers by sex (male and female). As a validation of the model, we compared observed and modeled rates for 2022.

In 2023, an estimated 1,967,906 new cancer cases were diagnosed in the US, with an age-adjusted preliminary rate of 462 cases per 100,000 standard population. In a validation analysis, observed and modeled rates for 2022 were similar (0.5% percentage difference, on average), indicating that the age-period-cohort models performed well.

Cancer registries are currently implementing data modernization strategies to improve timeliness of data. In the interim, preliminary incidence estimates can fill in gaps between cancer occurrence and cancer reporting. These early cancer rates and counts may be useful in guiding research and helping public health care professionals focus on areas of concern for cancer prevention and control efforts.