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Association between hemoglobin glycation index and all-cause mortality in patients with non-ST-segment elevation
Haodong Jiang1, Yanlong Zhao1, Yuanyuan Zhao1
1Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China.
Insights
The hemoglobin glycation index (HGI) may predict survival in non-ST-segment elevation myocardial infarction (NSTEMI) patients post-percutaneous coronary intervention (PCI). Higher HGI is linked to reduced all-cause mortality, suggesting its utility in risk stratification.
Area of Science:
- Cardiology
- Biomarkers
- Clinical Research
Background:
- The hemoglobin glycation index (HGI) is a potential cardiovascular risk marker.
- Prognostic value of HGI in non-ST-segment elevation myocardial infarction (NSTEMI) patients undergoing percutaneous coronary intervention (PCI) is not well-established.
Purpose of the Study:
- To investigate the association between HGI and all-cause mortality in NSTEMI patients treated with PCI.
Main Methods:
- A single-center cohort study of 635 NSTEMI patients who underwent PCI.
- Kaplan-Meier analysis, Cox regression, and restricted cubic spline (RCS) analysis were used.
- Median follow-up was 60 months.
Main Results:
- Higher HGI was associated with improved survival.
- A 1-unit increase in HGI correlated with a 43% lower risk of all-cause mortality (HR=0.57).
- The highest HGI tertile showed significantly lower mortality risk compared to the lowest tertile (HR=0.26).
Conclusions:
- HGI is associated with all-cause mortality in NSTEMI patients undergoing PCI.
- HGI may serve as a complementary marker for risk stratification in this patient group.
Background:
The hemoglobin glycation index (HGI) has emerged as a potential marker for cardiovascular risk stratification. However, its prognostic value in patients with non-ST-segment elevation myocardial infarction (NSTEMI) undergoing percutaneous coronary intervention (PCI) remains unclear. This study investigated the association between HGI and all-cause mortality in this population.
Methods:
This single-center cohort study included 635 patients with NSTEMI who underwent PCI between January 2016 and July 2023. The primary endpoint was all-cause mortality. Kaplan-Meier analysis, Cox regression, restricted cubic spline (RCS) analysis, and subgroup analyses were performed.
Results:
Over a median follow-up of 60 months, higher HGI was associated with more favorable survival. In the fully adjusted model, a 1-unit increase in HGI was associated with a 43% lower risk of all-cause mortality (HR=0.57, 95% CI: 0.40-0.82, P=0.002). Patients in the highest HGI tertile also had a lower risk of mortality than those in the lowest HGI tertile (HR=0.26, 95% CI: 0.10-0.66, P=0.004). RCS analysis indicated a linear inverse association. Exploratory subgroup analyses suggested that the inverse association appeared more evident in men than in women.
Conclusion:
HGI was associated with all-cause mortality and may serve as a complementary marker for risk stratification in patients with NSTEMI undergoing PCI.
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