Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

The Oral Microbiota

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Accurate serotype identification of <i>Streptococcus pneumoniae</i> using nanopore Cas9-targeted serotype identification (nCATSerotyping).

Journal of clinical microbiology·2025

Same author

The dual roles of peptidoglycans: NOD1 and NOD2 inversely regulate bone metabolism.

Experimental & molecular medicine·2025

Same author

Microbiota associated with caries and apical periodontitis: A next-generation sequencing study.

International endodontic journal·2025

Same author

A vaccine platform targeting lung-resident memory CD4<sup>+</sup> T-cells provides protection against heterosubtypic influenza infections in mice and ferrets.

Nature communications·2024

Same author

Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG as a Novel Intracanal Medicament Targeting Enterococcus faecalis Biofilm Formation.

Journal of microbiology (Seoul, Korea)·2024

Same author

Enterococcus Phage vB_EfaS_HEf13 as an Anti-Biofilm Agent Against Enterococcus faecalis.

Journal of microbiology (Seoul, Korea)·2024

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

Restoring Cellular Homeostasis as a Therapeutic Strategy for Periodontitis.

H Jang^1,2, J Im², D-S Lee^1,3

¹Laboratory for the Study of Regenerative Dental Medicine, Department of Oral Histology-Developmental Biology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.

Journal of Dental Research

|June 10, 2026

Summary

This summary is machine-generated.

CPNE7 peptide (SCPT) restores cellular function and homeostasis in periodontitis by improving redox balance and mitochondrial function. This peptide shows therapeutic potential for treating periodontal disease and bone loss.

Keywords:

CPNE7 Nrf2 signaling mitochondrial dysfunction oxidative stress periodontal inflammation redox homeostasis

More Related Videos

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Related Experiment Videos

Last Updated: Jun 11, 2026

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Area of Science:

Periodontal medicine
Cellular biology
Mitochondrial research

Background:

Periodontitis involves chronic inflammation, redox imbalance, and mitochondrial dysfunction, impairing periodontal tissues.
Current therapies inadequately restore compromised cellular function in the inflammatory microenvironment.
Restoring cellular homeostasis before regeneration may improve periodontal repair outcomes.

Purpose of the Study:

Investigate the role of CPNE7 in periodontal homeostasis.
Evaluate if selcopintide (SCPT), a CPNE7-derived peptide, restores cellular function under inflammatory conditions.
Assess SCPT's therapeutic effects in a mouse model of periodontitis.

Main Methods:

Analyzed CPNE7 expression in aged periodontal tissues.
Utilized Cpne7 knockout mice to study periodontitis progression.
Administered SCPT to inflammatory cell cultures and a mouse ligature-induced periodontitis model.
Assessed oxidative stress, redox balance, mitochondrial function, inflammation, apoptosis, and alveolar bone loss.

Main Results:

Reduced CPNE7 expression correlated with increased oxidative stress and decreased Nrf2 in aged tissues.
Cpne7 knockout mice showed aggravated periodontal damage and inflammation.
SCPT mitigated reactive oxygen species, restored redox balance, and improved mitochondrial function and morphology.
SCPT attenuated inflammatory signaling and apoptosis, activating the Nrf2 pathway.
Topical SCPT significantly reduced periodontal destruction and alveolar bone loss in vivo.

Conclusions:

CPNE7 is crucial for maintaining periodontal tissue homeostasis.
SCPT restores redox balance, mitochondrial function, and inflammatory stability in periodontitis.
CPNE7-derived peptides represent a promising therapeutic strategy for periodontitis treatment.