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Updated: Jun 11, 2026

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
10:16

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

Published on: February 10, 2012

Coronary physiology and intravascular imaging in surgical and percutaneous revascularization

Adham Elsherbini1, Shubh K Patel1, Tina B Marvasti2

  • 1Temerty Faculty of Medicine, University of Toronto.

Current Opinion in Cardiology
|June 10, 2026
PubMed

Insights

Coronary physiology and intravascular imaging improve percutaneous coronary intervention outcomes by guiding lesion selection and procedural optimization. Their role in coronary artery bypass grafting requires further investigation.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Imaging

Background:

  • Coronary angiography provides anatomical detail but not functional ischemia assessment.
  • Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are key revascularization strategies.
  • Accurate lesion assessment is crucial for effective revascularization.

Purpose of the Study:

  • To review current evidence on coronary physiology and intravascular imaging.
  • To evaluate their impact on PCI and surgical revascularization.
  • To delineate their established and investigational roles.

Main Methods:

  • Review of contemporary evidence on coronary physiology.
  • Analysis of data on intravascular imaging techniques (IVUS, OCT).
  • Assessment of studies comparing physiology-guided vs. angiography-guided interventions.

Main Results:

  • Physiology-guided PCI improves clinical outcomes and lesion selection.
  • Intravascular imaging (IVUS, OCT) enhances procedural optimization, especially in complex lesions.
  • Post-PCI physiologic testing often reveals residual ischemia despite angiographic success.
  • Role in CABG is investigational, with limited demonstrated clinical outcome improvement.

Conclusions:

  • Strong evidence supports integrating coronary physiology and intravascular imaging in PCI.
  • These modalities refine treatment decisions and improve procedural success.
  • Their application in CABG is not yet established and requires further research.
Abstract

Keywords:
coronary bypass surgerycoronary physiologyfunctional revascularizationintravascular imagingpercutaneous intervention

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