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Updated: Jun 11, 2026

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
Published on: May 11, 2015
[Diabetes mellitus: new insights and developments]
S T Jagroep1, D H van Raalte2, E W Meesters3
1The Department of Vascular Medicine of the Amsterdam UMC in Amsterdam and the Department of Internal Medicine of the Spaarne Gasthuis in Hoofddorp, the Netherlands.
Abstract:
Currently, there are estimated to be more than 1.2 million people with diabetes mellitus in the Netherlands. Of them, over 1 million have been diagnosed with type 2 diabetes mellitus and approximately 100,000 with type 1 diabetes mellitus. Type 2 diabetes mellitus frequently coexists with other metabolic disorders, such as being overweight, suffering from hypertension, hypercholesterolemia and kidney disease, and it is also often associated with oral health problems, particularly gingivitis and periodontitis, Recent developments in diabetes treatment make it possible to regulate insulin delivery more precisely and partially automatically by connecting an insulin pump to a continuous glucose monitoring sensor. In addition, the choice and sequence of glucose-lowering medications are becoming increasingly personalized, with sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists playing an important role in treatment.
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