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Updated: Jun 11, 2026

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
Published on: September 28, 2018
The multifaceted roles of receptor tyrosine pseudokinases in cellular signalling
Emily C Park1,2,3, Andrew P Thompson1,2,3, James M Murphy1,2,4
1Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Abstract:
Receptor tyrosine pseudokinases comprise approximately 10% of the receptor tyrosine kinase family and lack phosphotransferase activity due to substitutions of essential catalytic residues within their kinase folds. This review critically examines the eight human receptor tyrosine pseudokinases: EphA10, EphB6, HER3, PTK7, ROR1, ROR2, RYK, and STYK1. By reconciling recent structural and functional data, we highlight the diverse non-catalytic mechanisms these pseudokinases employ in cellular communication. This comprehensive analysis provides insights into non-canonical signalling pathways and highlights potential for therapeutic opportunities in diseases associated with pseudokinase dysfunction.
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