Related Experiment Video
Updated: Jun 11, 2026
05:30
The Combination of Mechanically Isolated Stromal Vascular Fraction and Fibrin Hydrogel: A Processing Protocol
Published on: November 17, 2023
Multifunctional Sargassum fusiforme Polysaccharide-Based Composite Sponges for Massive Hemorrhage
Muhammad Amir Ali1,2, Xialian Fan1,3, Yongchao Jiang1,2
1School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China.
ACS Applied Bio Materials
|June 10, 2026
Summary
Researchers developed advanced hemostatic sponges using alginate, chitosan, and Sargassum fusiforme polysaccharide (SFP). These sponges accelerate blood clotting, enhance tissue adhesion, and exhibit potent antibacterial activity, offering a promising solution for severe bleeding and infection control.
Area of Science:
- Biomaterials Science
- Hemostasis Research
- Wound Healing Technologies
Background:
- Massive hemorrhage from trauma or surgery is a leading cause of accidental death.
- Bacterial infection is a significant risk factor following bleeding events.
- Developing effective hemostatic agents to minimize blood loss is crucial.
Purpose of the Study:
- To improve the hemostatic efficacy and tissue adhesion of a novel biomaterial.
- To investigate the antibacterial properties and biocompatibility of the developed hemostatic material.
- To evaluate the potential of the composite sponge for rapid hemostasis in deep wounds.
Main Methods:
- Fabrication of composite hemostatic sponges incorporating alginate, chitosan, and Sargassum fusiforme polysaccharide (SFP) via electrostatic interactions.
- In vitro assays including tissue and blood cell adhesion, antibacterial activity tests (against E. coli and S. aureus), cytotoxicity, and hemolysis tests.
- In vivo hemostasis experiments to assess efficacy in reducing blood loss and hemostasis time.
- Cell proliferation assays and cell staining analyses to confirm biocompatibility.
Main Results:
- The composite sponges significantly promoted blood clot formation and enhanced tissue adhesion strength.
- Hemostasis time was effectively reduced, rapidly preventing blood loss in vivo.
- The ACSF 2.5 sponges demonstrated high antibacterial activity (92.6% against E. coli, 92.0% against S. aureus).
- Excellent in vitro biocompatibility was confirmed, with no observed cytotoxicity or hemolysis.
Conclusions:
- The developed composite hemostatic sponges show enhanced hemostatic efficacy and tissue adhesion.
- The sponges possess significant antibacterial properties, crucial for preventing wound infections.
- The material exhibits excellent biocompatibility, making it a safe and promising candidate for managing severe bleeding in deep wounds.
