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Trends in Pediatric Opioid Ingestion and Associated Factors in Washington State, 2014-2023
Nzuekoh N Nchinda1,2, James Leonard3, Alex Sirotzki3
1Department of Health Systems and Population Health, School of Public Health, University of Washington, Seattle, WA, USA.
Insights
Pediatric opioid ingestions, particularly fentanyl, surged in Washington State. Life-threatening effects were linked to socioeconomic disadvantage, highlighting urgent public health needs for prevention.
Area of Science:
- Public Health
- Toxicology
- Pediatric Medicine
Background:
- Childhood opioid intoxication is a growing concern in the US due to potent synthetic opioids.
- High-potency synthetic opioids pose significant risks to children.
Purpose of the Study:
- To evaluate trends in pediatric opioid ingestions in Washington State.
- To identify demographic factors associated with these ingestions.
Main Methods:
- Retrospective data review of non-therapeutic pediatric opioid exposures (2014-2023).
- Analysis of trends by opioid type and demographics.
- Logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- 2873 pediatric opioid ingestions reported; mean age 7.4 years, 52% female.
- Fentanyl ingestion increased by 9700%; hydrocodone and oxycodone decreased by 59% and 56%, respectively.
- Fentanyl ingestion, adolescent age, and neighborhood socioeconomic disadvantage increased odds of major adverse effects. 9 deaths reported.
Conclusions:
- Pediatric opioid ingestions in Washington show a sharp rise in fentanyl use.
- Life-threatening outcomes are disproportionately linked to socioeconomic disadvantage.
- Enhanced surveillance and prevention strategies are crucial for pediatric opioid ingestions.
Objectives:
Opioid intoxication among children is a growing public health concern given the increased prevalence of high-potency synthetic opioids in the United States. This study evaluated trends in pediatric opioid ingestions and associated demographic factors in Washington State.
Methods:
We conducted a retrospective data review of Washington Poison Center nontherapeutic pediatric opioid exposures reported from January 2014 through December 2023 among children and adolescents aged 0 to 17 years. We assessed trends based on opioid type and demographic factors. We performed logistic regression analysis and calculated odds ratios (ORs) and 95% CIs.
Results:
A total of 2873 pediatric opioid ingestions were reported; the mean (range) age was 7.4 (0.1-17.0) years, with a slight female predominance (52%). During the 10-year study period, we found a significant increase in fentanyl ingestion (9700%), a 59% decrease in hydrocodone ingestion, and a 56% decrease in oxycodone ingestion. Fentanyl ingestion (OR = 4.25; 95% CI, 2.88-6.22), adolescent age (OR = 2.00; 95% CI, 1.48-2.70), and a high-level neighborhood socioeconomic disadvantage (OR = 1.91; 95% CI, 1.36-2.73) had increased odds of a major effect (life threatening). We found 9 reported associated deaths.
Conclusions:
Recent trends of pediatric opioid ingestion in Washington State indicate a disproportionate increase in fentanyl ingestion and life-threatening effects associated with socioeconomically disadvantaged neighborhoods. Further studies and policy are needed to improve surveillance and prevention of pediatric opioid ingestions.
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