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Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
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Related Experiment Video

Updated: Jun 11, 2026

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
10:00

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells

Published on: December 11, 2020

[Sleep disorders and oxidative stress].

A B Kozhokaru1, V I Shmyrev1, D I Lebedeva2

  • 1Central State Medical Academy of the Presidential Executive Office of the Russian Federation, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|June 10, 2026
PubMed
Summary
This summary is machine-generated.

Sleep disorders and oxidative stress have a two-way relationship, worsening cognitive function. Antioxidants may help improve sleep by reducing oxidative stress and inflammation.

Keywords:
antioxidantscognitive impairmentintermittent hypoxiamelatoninoxidative stresssleep deprivationsleep disorders

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Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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Published on: September 22, 2020

Area of Science:

  • Neuroscience
  • Biochemistry
  • Sleep Medicine

Background:

  • Sleep disorders are a major health concern linked to oxidative stress and cognitive decline.
  • A bidirectional relationship exists between sleep disturbances and increased oxidative stress.

Purpose of the Study:

  • To review the association between sleep disorders and oxidative stress.
  • To explore the role of antioxidants in managing sleep disorders.

Main Methods:

  • Literature review of current evidence.
  • Analysis of the mechanisms linking sleep disorders, oxidative stress, and cognitive impairment.
  • Examination of the therapeutic potential of antioxidants.

Main Results:

  • Sleep deprivation and insomnia increase reactive oxygen species, mitochondrial dysfunction, and neuroinflammation.
  • Obstructive sleep apnea causes neuronal damage via intermittent hypoxia.
  • NRF2 and ferroptosis pathways are implicated in sleep disorder pathogenesis.

Conclusions:

  • Antioxidants like melatonin and vitamins may improve sleep by reducing oxidative stress.
  • Targeting oxidative stress pathways presents a potential therapeutic strategy for sleep disorders.