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Reversible Thermoactuation Unlocks Minimally Invasive Implantation and Retrieval of Soft Bioelectronics.

Qinyi Zhao1, Qiliang Liu1, Bin Li2

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Summary

Researchers developed a novel thermoresponsive polymer (Trap) for reversible bioelectronic devices. This material enables minimally invasive implantation and retrieval, overcoming key challenges in clinical translation.

Keywords:
dual‐crystalline competition mechanismminimally invasive and retrieval bioelectronicsneural interfacesreversible thermoresponsive shape memory polymers

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Science

Background:

  • Minimally invasive bioelectronic device delivery is hindered by irreversible deployment, complicating retrieval and limiting clinical use.
  • Current bioelectronic interfaces often require traumatic surgical procedures for implantation and removal.

Purpose of the Study:

  • To introduce a novel thermoresponsive, reversible-actuating polymer (Trap) for minimally invasive bioelectronic device delivery and retrieval.
  • To demonstrate the material's capability for stress-free shape memory actuation within a physiological temperature range.
  • To enable stable, long-term electrophysiological interfacing with reduced surgical invasiveness.

Main Methods:

  • Development of a novel thermoresponsive polymer (Trap) with a unique dual-crystalline structure.
  • Characterization of the polymer's competitive crystallization and solid-solid phase switching.
  • Evaluation of bidirectional, stress-free shape memory actuation (rapid, fatigue-resistant, large reversible strain).
  • Demonstration of microinvasive deployment and retraction of Trap-based neural electrodes.

Main Results:

  • Trap enables reversible transitions between 1D and 2D/3D geometries without mechanical loading.
  • The polymer exhibits rapid (<3 s), fatigue-resistant actuation with ~30.17% reversible strain within 10°C-37°C.
  • Trap-based neural electrodes were successfully implanted and retrieved through a ~5 mm incision.
  • Stable electrophysiological interfacing was achieved over weeks to months using the reversible biointerface.

Conclusions:

  • The novel Trap polymer provides a material-centered solution for reversible biointerfaces.
  • This innovation resolves the conflict between surgical invasiveness and device retrievability in bioelectronics.
  • The developed material facilitates minimally invasive implantation and retrieval, paving the way for advanced clinical translation of bioelectronic devices.