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Updated: Jun 12, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Analysis of the Degradation Pathways, Cytotoxicity, and Antimicrobial Properties of Block Amphiphilic Aliphatic
Natalia Śmigiel-Gac1, Anna Smola-Dmochowska1, Renata Barczyńska-Felusiak2
1Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
Abstract:
This study evaluates the antibacterial activity, cytotoxicity, and hydrolytic degradation of block poly(esteramine)s synthesized via the copolymerization of L-lactide and glycolide in the presence of a macroinitiator derived from DEA, HEDEA, and Dimethyl L-tartrate. The findings highlight the significant potential of these polymers for biomedical use. Under simulated physiological conditions, the copolymers exhibit rapid degradation, reaching total hydrolysis within 14 to 30 days. The degradation time strongly depends on the copolymer composition. The inclusion of hydrophilic blocks containing amino groups accelerates this process, as these groups exert a catalytic effect on ester bond hydrolysis within both the polyesteramine and PLAGA segments.
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