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Heterogeneous Longitudinal Changes in Corneal Epithelial and Stromal Thicknesses in Patients With Very Asymmetric
Shizuka Koh1, Ryota Inoue, Renato Ambrósio
1Department of Innovative Visual Science (S.K., R.I.), The University of Osaka Graduate School of Medicine, Osaka, Japan; Department of Ophthalmology (S.K., K.N.), The University of Osaka Graduate School of Medicine, Osaka, Japan; SEED Co. (R.I.), Ltd., Tokyo, Japan; Instituto de Olhos Renato Ambrósio (R.A.), Rio Vision Hospital and Department of Ophthalmology, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil; London Vision Clinic (D.Z.R., T.J.A.), London, United Kingdom; Columbia University Medical Center (D.Z.R.), New York; and Sorbonne Université (D.Z.R.), Paris, France; and Biomedical Science Research Institute (D.Z.R.), Ulster University, Coleraine, United Kingdom.
Abstract:
This study aimed to investigate the longitudinal changes in corneal epithelial and stromal thicknesses in eyes with very asymmetric ectasia that appeared clinically and topographically normal at baseline. Fourteen eyes from 14 patients underwent serial evaluation using corneal topography, corneal tomography, and corneal biomechanical assessment. Based on baseline tomographic and biomechanical parameters, eyes were classified into two groups. Over a mean follow-up of 54 months, eyes with normal baseline parameters showed minimal changes in stromal thickness, whereas a subset of eyes with abnormal baseline indices demonstrated measurable stromal thinning exceeding physiological variability. By contrast, epithelial thickness changes were small and inconsistent across all patients. These findings indicate that eyes with very asymmetric ectasia represent a heterogeneous population and that the longitudinal assessment of corneal layer-specific changes may provide additional insights beyond that derived from cross-sectional evaluation alone.
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