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Relationship between gut microbiota and neurodegenerative diseases: A scientometric visualization analysis
Shan Wang1, Xiaoyi Lin2, Zhengzhe Sun3
1Hefei Hua'an Brain Hospital, China.
Computational Biology and Chemistry
|June 10, 2026
Summary
Research on gut microbiota and neurodegenerative diseases has evolved. Early work focused on microbial alterations and immunology, with current research emphasizing mechanisms and applications for precision medicine.
Area of Science:
- Neuroscience
- Microbiology
- Immunology
Background:
- Neurodegenerative diseases involve progressive neuron loss and functional impairment.
- The gut microbiome's role in neurodegeneration is a growing research area.
- Bibliometric analysis is key to understanding research trends in this field.
Purpose of the Study:
- To systematically review research advances in gut microbiota and neurodegenerative diseases over two decades.
- To identify key discoveries and current research landscape.
- To highlight emerging trajectories for future investigation.
Main Methods:
- Bibliometric analysis of literature from 2005-2024.
- Utilized Web of Science Core Collection for data retrieval.
- Employed CiteSpace, Scimago Graphica, and VOSviewer for analysis.
Main Results:
- Initial research focused on gut microbiota alterations and immunological mechanisms.
- Current focus has shifted to microbiota mechanisms of action and application value in neurodegenerative diseases.
- Future directions point towards targeted gut microbiota interventions for precision treatment.
Conclusions:
- This review provides a comprehensive overview of gut microbiota and neurodegenerative disease research.
- Key discoveries and research trajectories over the past two decades are highlighted.
- Offers valuable references for researchers and outlines future investigation avenues.
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