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Related Concept Videos

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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Ribosome Profiling

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Ribozymes02:47

Ribozymes

The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
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RNA Editing02:23

RNA Editing

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Experimental RNAi

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Related Experiment Video

Updated: Jun 12, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Classified review of circular RNA databases and web-based resources.

Zakie Saadat1, Seyed Mahdi Ahmadi1, Javad Rafiee2

  • 1Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Computational Biology and Chemistry
|June 10, 2026
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are key non-coding RNAs with unique structures. This review classifies and compares circRNA databases, aiding researchers in selecting appropriate tools for their studies.

Keywords:
BioinformaticsCircRNA analysisCircular RNAsDatabasesOnline tools

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Last Updated: Jun 12, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs with a distinct closed-loop structure, lacking 5' cap and 3' polyA tails.
  • Many circRNAs are conserved across species and exhibit tissue-specific or developmental stage-specific expression, playing roles in miRNA sponging and protein binding.
  • Advancements in experimental and computational methods have generated extensive data on circRNA discovery and function.

Purpose of the Study:

  • To classify the diverse aspects of circRNAs covered by existing databases.
  • To review and compare current circRNA databases based on the data they provide.
  • To serve as a reference for researchers in selecting suitable databases and to identify areas for future development.

Main Methods:

  • Systematic review and classification of circRNA databases.
  • Comparative analysis of database content and features.
  • Literature search for relevant experimental and computational studies on circRNAs.

Main Results:

  • Identified and categorized various circRNA databases based on their data coverage.
  • Compared databases regarding the types of information they offer (e.g., expression, function, conservation).
  • Highlighted the importance of selecting appropriate databases for efficient circRNA research.

Conclusions:

  • A comprehensive classification and comparison of circRNA databases are presented.
  • This review assists researchers in navigating the landscape of circRNA data resources.
  • The findings can guide future database development to address existing gaps in circRNA information.