Related Experiment Video
Updated: Jun 12, 2026

Modeling Healthy and Dysbiotic Vaginal Microenvironments in a Human Vagina-on-a-Chip
Published on: February 16, 2024
The correlation between vaginal microbiome dysbiosis and recurrent spontaneous abortion
Mengzhen Zheng1, Weiwei Lun1, Pengran Wang1
1Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China.
Abstract:
In recent years, the role of the vaginal microbiota in pregnancy maintenance has garnered increasing attention. Extensive research indicates that vaginal dysbiosis is closely associated with various adverse pregnancy outcomes, including ectopic pregnancy, miscarriage, preterm birth, and premature rupture of membranes. Recurrent spontaneous abortion (RSA) affects approximately 1-5% of women of childbearing age and has a complex etiology, with infection implicated in about 4% of cases. This systematic review examines the compositional characteristics of the vaginal microbiota, its dynamic changes during pregnancy, and the underlying mechanisms linking it to RSA. It focuses on the protective role of lactobacilli, ascending pathogen infection, and local immune regulation, aiming to provide a novel theoretical foundation for the prevention, risk prediction, and personalized treatment of RSA.
Related Concept Videos
Microbiota of the Urogenital Tract
Dysbiosis of the Gut Microbiota
Development of Human Microbiota
Development of the Oral Microbiota
Candidiasis
Microbiota Modulation by Antibiotics

