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Updated: Jun 12, 2026

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Published on: August 16, 2018
Galanin receptor 2: A multifunctional modulator in neurological diseases - Structure, mechanisms, and therapeutic
Yuxin Dai1, Zitong Zhao2, Yuting Song1
1Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Abstract:
Galanin receptor 2 (GALR2), as a subtype of neuropeptide galanin receptor, is predominantly expressed in the central and peripheral nervous systems. Accumulating evidence suggests that GALR2 is involved in the pathogenesis of depression, Alzheimer's disease, epilepsy, neuropathic pain, multiple sclerosis, as well as in neurological tumors. Here, we summarize the current knowledge on the molecular architecture, signal transduction mechanisms, and diverse biological functions of GALR2. In addition, we also discuss the involvement of GALR2 in neurological diseases, with a particular emphasis on evaluating its potential as a novel and viable therapeutic target for future drug development.
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