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CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy
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Published on: March 12, 2018

Correction: F2,6BP restores mitochondrial genome integrity in Huntington's disease

Anirban Chakraborty, Santi M Mandal, Mikita Mankevich

    The Journal of Biological Chemistry
    |June 10, 2026
    PubMed
    Summary

    No abstract available in PubMed .

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    Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
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