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Published on: February 22, 2019
Measles: Why the vaccine still works after 60 years
Katsumi Maenaka1, Shunsuke Kita2, Hideo Fukuhara3
1Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan; Division of Pathogen Structure, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan; Hokkaido University Institute for Vaccine Research & Development, Sapporo 001-0021, Japan; Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
None:
The measles vaccine provides lifelong protection despite high virus mutation rates. In this issue of Cell Host & Microbe, Acciani et al. demonstrate that vaccine-induced antibodies target highly conserved epitopes within the viral glycoproteins H and F, identifying a "vulnerability nexus" that ensures antigenic stability.
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