Related Experiment Video
Updated: Jun 12, 2026
09:25
Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
Published on: June 28, 2013
A human model of progressive pancreatic neoplasia and cancer
David Escobar1, Howard C Crawford1
1Department of Surgery, Henry Ford Health, Detroit, MI 48202, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA.
Developmental Cell
|June 10, 2026
Abstract:
In this issue of Developmental Cell, Zhang et al.1 use human pancreatic progenitor organoids to define the tumorigenic threshold governed by mutations in the four most altered genes in PDAC. They connect this transition to AP-1-driven chromatin remodeling, TET1 suppression, and epigenetic restriction of pancreatic lineage programs.
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