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Updated: Jun 12, 2026

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

Attenuated hypothalamic response to fructose via a dedicated gut-brain pathway

Aaron D McKnight1, Alan de Araujo2, Fang-Yu Hsu2

  • 1Monell Chemical Senses Center, Philadelphia, PA 19104, USA; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA.

Neuron
|June 10, 2026
PubMed
Summary

Fructose uniquely impacts hunger signals, unlike glucose. This sugar activates a specific gut-brain pathway, influencing food preference by modulating agouti-related protein (AgRP) neuron activity.

Keywords:
AgRPPYYY2 receptorcalcium imagingfiber photometryfructoseglucosehypothalamussugarvagus nerve

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