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Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

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A Conservative Framework to Derive Preliminary Canine Toxicity Reference Values From Human Data for Contaminated Soil

Maxime Louzon1, Noah Casañas2, Stéphane Vircondelet2

  • 1SNAILY, Saint Martin d'Hères, France.

Journal of Applied Toxicology : JAT
|June 10, 2026
PubMed
Summary

This study adapts human toxicity reference values (TRVs) for canine health risk assessments, creating dog-specific TRVs for soil contaminants. This framework supports better environmental risk management for companion animals and advances a One Health approach.

Keywords:
dogsdomestic animalhealth risk assessmentmetalspolluted soilssentinel species

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Area of Science:

  • Environmental Toxicology
  • Veterinary Public Health
  • Risk Assessment

Background:

  • Environmental soil contamination poses risks to humans and companion animals like dogs.
  • Current health risk assessments are anthropocentric, neglecting domestic animal exposure to soil contaminants.
  • Dogs may experience significant exposure to soil contaminants through ingestion.

Purpose of the Study:

  • To develop a novel framework for adapting human toxicity reference values (TRVs) to canine health risk assessment.
  • To establish canine-specific TRVs for threshold-based ingestion exposures to soil pollutants.
  • To promote a One Health perspective in environmental risk management.

Main Methods:

  • Compiled human ingestion-based TRVs for common soil pollutants.
  • Extrapolated human TRVs to dogs using allometric scaling (body mass and metabolic rate).
  • Proposed a methodology for canine-specific TRV derivation.

Main Results:

  • Successfully adapted human TRVs to derive canine-specific TRVs.
  • Established a scientifically grounded framework for canine environmental risk assessment.
  • Identified a gap in toxicokinetic data for further refinement.

Conclusions:

  • The proposed methodology provides a transparent and adaptable basis for including domestic animals in environmental risk assessments.
  • Scientifically grounded, canine-specific TRVs are crucial for contaminated land management.
  • Recognizing dogs as co-exposed receptors and sentinels enhances holistic health protection across species.