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Updated: Jun 12, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
Published on: April 1, 2019
[Microvascular Reconstruction of the Laryngotracheal Junction]
Miguel Goncalves1, Stephan Hackenberg1, Agmal Scherzad1
1Universitätsklinikum Würzburg, Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Hals-Chirurgie, Deutschland, Würzburg.
Background:
The laryngotracheal junction (LTJ) is a functionally critical zone, due to its narrow anatomy, complex airflow dynamics, and proximity to the glottis and cricoid cartilage. Extensive stenoses, cricoid defects, and stomal anterior wall loss frequently exceed the possibilities of conventional resection and reconstruction.
Objective:
To outline the current role of microvascular reconstruction at the LTJ, with a focus on indications, techniques, and limitations from the perspective of otolaryngology and thoracic surgery.
Methods:
Narrative literature review of clinically established flap reconstruction techniques at the LTJ, including recent case series and key publications.
Results:
For short, non-pretreated defects, cricotracheal resection and segmental tracheal resection with end-to-end anastomosis remain the standard of care. Microvascular reconstructions are mainly used for long, circumferential LTJ defects, extensive cricoid loss, previously irradiated or multiply operated regions, and complex treatment interventions. The radial forearm free flap is currently the best-established option for long tracheal and laryngotracheal defects and can be combined with cartilage reinforcement or a mucosal lining. Osseous flaps such as the medial femoral condyle flap and the thoracodorsal artery scapular tip flap allow larynx-preserving reconstruction, with restoration of a stable ring or posterior framework in selected cases. Prefabricated constructs, ALT-based flaps, jejunal grafts, and pedicled flaps play an adjunctive role in borderline and salvage situations.
Conclusion:
Microvascular reconstruction extends the therapeutic spectrum for LTJ surgery beyond conventional resection techniques and can provide a functional airway in highly complex situations and with acceptable morbidity. Given the limited evidence base from case series, interdisciplinary planning and centralisation of these procedures in experienced centres are essential.
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