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Expression characteristics of INPP4B, PTEN and SGK3 in papillary thyroid carcinoma and their correlations
Qingshuang Bai1, Cailan Wu1, Linna Shen2
1Department of Nuclear Medicine, Tianjin Fourth Central Hospital, Tianjin 300140, China; Department of Nuclear Medicine, The Fourth Central Hospital Affiliated to Tianjin Medical University, Tianjin 300140, China.
Objective:
To investigate the expression characteristics of type II inositol polyphosphate 4-phosphatase (INPP4B), phosphatase and tensin homolog (PTEN) and serum/glucocorticoid-regulated kinase 3 (SGK3) in papillary thyroid carcinoma (PTC) and to assess the correlations among their expressions.
Methods:
Sixty tumor tissues from patients with PTC and corresponding adjacent normal thyroid tissues were obtained. Messenger RNA (mRNA) expression levels of INPP4B and protein expression levels of INPP4B, PTEN, and SGK3 were assessed using quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC), respectively. Associations between protein expression levels and clinicopathological characteristics were analyzed.
Results:
Protein expression levels of INPP4B and SGK3 were significantly elevated in PTC tissues compared with adjacent normal tissues (p < 0.05), whereas PTEN protein expression was significantly reduced (p < 0.05). Expression of INPP4B demonstrated a positive correlation with SGK3 (Spearman r = 0.4436, p < 0.05) and a weak negative correlation with PTEN (Spearman r = -0.2586, p < 0.05). Elevated SGK3 expression was significantly associated with lymph node metastasis in patients with PTC (p = 0.0425). Protein expression levels of INPP4B, PTEN, and SGK3 were not significantly associated with sex, age, nodule size, presence of calcification, or TNM stage (p > 0.05).
Conclusion:
INPP4B, PTEN, and SGK3 are abnormally expressed in PTC tissues, and there are significant correlations among their expressions. SGK3 expression may be associated with lymph node metastasis of PTC, which provides basic data for exploring the occurrence and development of PTC. Further studies are required to clarify their underlying molecular mechanisms.
