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Long-Term Changes in Physical Activity Among Cancer Survivors After Concurrent Chemoradiation Therapy: A Prospective
Adel Zakharia1, Rafi Kabarriti1, William R Bodner1
1Department of Radiation Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York.
Summary
Long-term cancer survivors show significantly reduced physical activity after chemoradiotherapy. Activity decline was substantial, with limited ability to predict it using patient or disease factors.
Area of Science:
- Oncology
- Rehabilitation Medicine
- Medical Technology
Background:
- Objective assessment of long-term physical activity in cancer survivors post-chemoradiotherapy is limited.
- Wearable activity monitors offer a method for objective data collection.
- Understanding long-term activity trends is crucial for survivor care and recovery.
Purpose of the Study:
- To assess long-term physical activity levels in cancer survivors after curative-intent chemoradiotherapy.
- To quantify the change in physical activity from baseline to long-term follow-up.
- To explore associations between clinical factors and activity decline.
Main Methods:
- Enrolled 17 cancer survivors a mean of 5.4 years post-chemoradiotherapy.
- Utilized wearable activity monitors to collect step count data.
- Compared baseline and long-term follow-up step count averages.
Main Results:
- 82% of participants had lower step counts at long-term follow-up compared to baseline.
- Median relative decline in step count was -43% (annualized rate of -12% per year).
- In lung cancer survivors, higher heart radiotherapy dose correlated with greater activity decline (p=0.034).
Conclusions:
- Physical activity remains substantially reduced in long-term cancer survivors post-chemoradiotherapy.
- Conventional clinical factors had limited predictive power for activity decline.
- Further research may be needed to identify predictors and interventions for activity restoration.
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