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Published on: September 18, 2018
Evaporative coupled with antisolvent crystallization for additive manufacturing of personalized solid dosage forms
Aliou Mbodji1, Andrea Arroyo Gomez2, Gianelle Bigio Silva2
1Crystallization Design Institute, Molecular Sciences Research Center, University of Puerto Rico, San Juan, PR 00926, United States; Department of Pharmaceutical Sciences, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, United States.
International Journal of Pharmaceutics
|June 10, 2026
Summary
This study introduces a novel additive manufacturing method for creating personalized medicine doses. The process precisely formulates crystalline solid dispersions (CrySoD) with customizable drug strengths for tailored pharmaceutical therapy.
Area of Science:
- Pharmaceutical Manufacturing
- Personalized Medicine
- Materials Science
Background:
- Flexible solid dosage manufacturing is crucial for personalized medicine.
- Current platforms require advanced precision dosing capabilities.
Purpose of the Study:
- To develop a solution-based additive manufacturing platform for individualized solid dosage forms.
- To demonstrate precise dose control using a model-informed algorithm.
Main Methods:
- Utilized additive manufacturing to create crystalline solid dispersions (CrySoD).
- Employed evaporative antisolvent crystallization of warfarin sodium isopropanol (WS-IPA) within a polymer matrix (PEG).
- Controlled critical process parameters (temperature, concentration, antisolvent composition).
Main Results:
- Achieved precise dosing in increments as small as 0.2 mg.
- Manufactured WS-IPA CrySoD capsules meeting key performance metrics (dissolution) comparable to commercial tablets (Coumadin®).
- Successfully obtained the commercial crystalline solid form of WS-IPA.
Conclusions:
- The study provides a generalizable proof-of-concept for a model-informed solid dosage formulation platform.
- This approach enables process intensification for personalized pharmaceutical therapy.
- Results support further research in personalized drug substances, regulatory science, and technoeconomic analysis.
Keywords:
Additive manufacturingAntisolvent-evaporative crystallizationPersonalized medicineProcess intensificationSolid dispersionsSolid dosage formWarfarin sodium isopropanolMore Related Videos
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