Abdominopelvic Pain and Overlapping Pain Conditions in Patients With Mayer-Rokitansky-Küster-Hauser Syndrome
Samantha J Lowe1, Sara J Vincent1, Megan F Sumida2
1Baylor College of Medicine, Houston, Texas.
Study Objective:
Our objectives were to estimate the prevalence of abdominopelvic pain (AP) in patients with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH), compare the prevalence of AP in patients with anatomic variations and extragenital anomalies in MRKH, and estimate the prevalence of overlapping pain conditions (OPC) in patients with MRKH.
Methods:
Retrospective cohort study of MRKH patients seen at an academic center (2014-2024), identified using ICD-10 codes for uterine agenesis (UA) or vaginal agenesis (VA). Inclusion criteria included a confirmed diagnosis of MRKH. Patients with 46,XY karyotypes were excluded. Descriptive statistics were performed. Chi-square analyses were used for categorical variables and 2-tailed student's t tests were used for continuous variables to compare features of MRKH patients, including presence/absence of uterine remnants (UR). Multivariate logistic regression was performed to further evaluate associations with AP.
Results:
A total of 117 patients were identified and subcategorized by UR status (UR n = 63, no UR n = 54), and MRKH type (Type 1 n = 65, Type 2 n = 52). Overall, 36.8% of patients (n = 43) reported persistent AP and 20.5% of patients (n = 24) cyclic AP. UR were associated with persistent (p = .008) and cyclic AP (p = .001). There was no association between MRKH type and persistent (p = .732) or cyclic AP (p = .282). 23.9% of (n = 28) patients were treated for ≥1 OPC, with migraine headache (n = 21) and IBS (n = 8) being most common.
Conclusions:
Given the burden of persistent and cyclic AP among MRKH patients, careful and timely evaluation for pain is warranted. Management should focus on clinical presentation over imaging findings.
Related Concept Videos
Abdominal Regions and Quadrants
The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersects at the patient's umbilicus (navel). The four quadrants...
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Pyloric Obstruction


