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Neurocognitive Late Effects Among Childhood Cancer Survivors: A Holistic Review of Clinical Risk Factors
Rachel S Werk1, Katharine Rae Lange2
1Division of Hematology, Oncology, NeuroOncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 East Chicago Avenue Box 30, Chicago, IL 60611, USA.
Abstract:
Childhood cancer survivors are at risk for neurocognitive deficits because of the past treatment received and, if involving the central nervous system, the malignancy itself. It is vital to maintain a holistic perspective in caring for childhood cancer survivors to identify and address the multiple factors associated with neurocognitive outcomes in this patient population in addition to the cancer and treatment received. In this review, we provide an overview of the many factors of a cancer experience that can impact neurocognition and discuss opportunities for clinician screening.
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