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Updated: Jun 12, 2026

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
08:23

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

Elevated CSF Beta Trace Protein Levels in Patients with CSF-Venous Fistulas.

Ian T Mark1, Parnian Habibi2, D K Kim2

  • 1From the Department of Radiology (I.T.M., P.H., D.K.K., G.B.L., P.P.M., C.M.C., M.P.O., D.S., J.V., A.A.M., J.B., B.J.-T.,W.B.), Neurology (J.C.-G.), Laboratory medicine and Pathology (J.W.M.) and Quantitative Health Sciences (N.L., S.G.), Mayo Clinic, Rochester, MN. Mark.Ian@mayo.edu.

AJNR. American Journal of Neuroradiology
|June 10, 2026
PubMed
Summary

Cerebrospinal fluid Beta-trace protein (BTP) levels can help diagnose cerebrospinal fluid-venous fistulas (CVF). Higher BTP levels in CSF indicate a higher likelihood of a positive myelogram for CVF.

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Last Updated: Jun 12, 2026

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
08:23

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

Area of Science:

  • Neurology
  • Biomarkers
  • Diagnostic Imaging

Background:

  • Spontaneous Intracranial Hypotension is challenging to diagnose due to a lack of objective biomarkers.
  • Beta-trace protein (BTP) is abundant in cerebrospinal fluid (CSF) and originates from the central nervous system (CNS).

Purpose of the Study:

  • To evaluate CSF BTP levels in patients undergoing lateral decubitus myelography for cerebrospinal fluid-venous fistula (CVF) diagnosis.
  • To determine if CSF BTP levels can differentiate between positive and negative myelogram results for CVF.

Main Methods:

  • 71 patients undergoing lateral decubitus myelography had their CSF BTP levels measured.
  • Myelogram results were classified as definite, negative, or indeterminate by two independent neuroradiologists.
  • Multinomial logistic regression was used to associate BTP levels with myelogram results, adjusting for age and sex.

Main Results:

  • Patients with definite CVF (positive myelogram) had a mean CSF BTP of 34.4 mg/L, compared to 16.8 mg/L in those with negative myelograms (p < 0.0001).
  • Indeterminate myelogram results showed intermediate BTP levels (21.2 mg/L).
  • Each unit increase in CSF BTP was associated with a 48% increase in the odds of a definite positive myelogram for CVF.

Conclusions:

  • CSF BTP levels are significantly elevated in patients with confirmed cerebrospinal fluid-venous fistulas (CVF).
  • CSF BTP shows potential as a non-invasive biomarker to aid in the diagnosis of CVF, complementing myelography.