Related Experiment Videos
A Case of Adult-Onset Still's Disease Diagnosed Following Treatment for Scrub Typhus
Asuka Tani1, Haruna Matsuo1, Keita Fujikawa1
1Department of Rheumatology, Japan Community Healthcare Organization, Isahaya General Hospital, Japan.
Abstract:
A 28-year-old woman, previously diagnosed with seronegative rheumatoid arthritis, was admitted with fever, vomiting, and diarrhea. She developed septic shock with disseminated intravascular coagulation and was treated with antibiotics, noradrenaline, prednisolone, and thrombomodulin. On day 3, a rash appeared, and polymerase chain reaction detected Orientia tsutsugamushi deoxyribonucleic acid, thus confirming the diagnosis of scrub typhus. Her symptoms resolved after minocycline treatment. After tapering the prednisolone, fever, rash, and arthralgia recurred. Laboratory tests revealed elevated ferritin and interleukin-18 levels. After excluding other causes, adult-onset Still's disease (AOSD) was diagnosed in this patient. The patient exhibited a rapid improvement following tocilizumab treatment. Scrub typhus and AOSD share overlapping features that complicate diagnosis.
Related Concept Videos
Rocky Mountain Spotted Fever
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Endocarditis II: Clinical Features of Infective Endocarditis