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Related Experiment Video

Updated: Jun 12, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

ER-phagy orchestrates virus-host interactions across kingdoms.

Ruiqi Wang¹, Qianshen Zhang¹, Yiping Wang¹

¹State Key Laboratory of Plant Environmental Resilience, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Trends in Microbiology

|June 10, 2026

Summary

This summary is machine-generated.

Endoplasmic reticulum (ER) homeostasis is maintained by ER-phagy, a process that also acts as a defense against viruses by degrading viral components. This pathway is a promising target for developing new antiviral therapies.

Keywords:

ER remodeling ER-phagy antiviral defense counterdefense viral infection

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Last Updated: Jun 12, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Area of Science:

Cellular biology
Immunology
Virology

Background:

Endoplasmic reticulum (ER) homeostasis is crucial for cellular function.
ER-phagy, also known as reticulophagy, is a selective autophagy process.
ER-phagy plays a role in cellular defense mechanisms.

Purpose of the Study:

To elucidate the role of ER-phagy in antiviral defense.
To understand the interplay between viruses and the ER-phagy pathway.
To explore ER-phagy as a potential target for antiviral interventions.

Main Methods:

Literature review and synthesis of existing research on ER-phagy and viral infections.
Analysis of molecular mechanisms underlying ER-phagy in response to viral pathogens.
Comparative analysis of ER-phagy across different kingdoms in the context of viral defense.

Main Results:

ER-phagy is a conserved mechanism that restricts viral infections across various organisms.
This process targets viral replication organelles and degrades viral components.
Viruses have evolved strategies to counteract or exploit the ER-phagy pathway.

Conclusions:

ER-phagy is a significant component of the innate immune system against viral invaders.
The dynamic interaction between ER-phagy and viruses influences infection outcomes.
Targeting ER-phagy presents a promising strategy for novel antiviral therapeutic development.