Corvis ST parameters in primary open angle and angle closure glaucoma after propensity score matching

Area of Science:

• Ophthalmology
• Glaucoma Research
• Biomedical Engineering

Background:

• Primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) are distinct glaucoma types.
• Corvis ST tonometry (CST) measures corneal biomechanics, potentially offering insights into glaucoma pathophysiology.
• Understanding CST parameter differences could aid in glaucoma diagnosis and management.

Purpose of the Study:

• To compare Corvis ST tonometry (CST) parameters between eyes with POAG and PACG.
• To identify potential biomechanical differences relevant to glaucoma subtypes.
• To evaluate the utility of CST in differentiating between POAG and PACG.

Main Methods:

• Retrospective analysis of 48 eyes with POAG and 48 eyes with PACG.
• Propensity score matching to control for confounding factors.
• Comparison of 12 CST parameters using linear mixed-effects models with adjustments for covariates.
• Benjamini-Hochberg procedure for multiple comparison correction.

Main Results:

• Uncorrected analysis suggested trends of greater indentation-related responses in PACG eyes (longer A2 time, greater A2 deformation amplitude, greater whole-eye movement).
• These trends were not statistically significant after correction for multiple testing.
• No statistically significant differences in CST parameters were found between POAG and PACG eyes after covariate adjustment and multiple comparison correction.

Conclusions:

• This study did not demonstrate statistically significant differences in Corvis ST tonometry parameters between POAG and PACG eyes.
• The observed uncorrected trends in PACG eyes are considered exploratory and require further investigation.
• CST may not be a primary tool for differentiating between POAG and PACG based on current analysis.