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Related Experiment Video

Updated: Jun 12, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

A prognostic human brain network for diffuse midline glioma.

Jai Sidpra1, Valentina Lind2,3,4, Alexander L Cohen5,6,7,8

  • 1Developmental Biology and Cancer Section, University College London Great Ormond Street Institute of Child Health, London, UK. jai.sidpra@ucl.ac.uk.

Nature
|June 10, 2026
PubMed

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Summary

Diffuse midline gliomas (DMGs) exploit brain networks for growth. Mapping these tumor networks reveals a conserved brain network linked to survival in children with these aggressive central nervous system tumors.

Area of Science:

  • Neuro-oncology
  • Systems neuroscience
  • Pediatric oncology

Background:

  • Diffuse midline gliomas (DMGs) are aggressive childhood brain tumors.
  • DMGs form extensive networks in animal models, promoting growth and invasion.
  • The organization and clinical impact of these networks in humans are unknown.

Purpose of the Study:

  • To map the brain-wide connectivity of DMGs in living patients.
  • To define a conserved DMG network and assess its association with patient survival.
  • To investigate the relationship between tumor growth, neurometabolic changes, and developmental timing.

Main Methods:

  • Development of tumor network mapping to compute brain-wide connectivity profiles.
  • Analysis of functional connectivity with a defined DMG network.

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Related Experiment Videos

Last Updated: Jun 12, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

  • Integration of single-nucleus RNA sequencing data and neuroimaging.

    • Main Results:

    • A conserved brain network (DMG network) was identified across pontine and thalamic DMGs.
    • Tumor connectivity with the DMG network predicted patient survival across validation cohorts.
    • Tumor growth and neurometabolic changes aligned with DMG network trajectories and developmental stages.
    • High-connectivity DMGs showed enrichment of synaptic genes, and partial resection improved survival.

    Conclusions:

    • DMGs establish a conserved, prognostically significant brain network in children.
    • This network is exploited by DMGs to promote tumor growth and invasion.
    • Targeting these brain circuits may offer new therapeutic strategies for pediatric gliomas.