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Updated: Jun 12, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
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Porphyromonas gingivalis disrupts hippocampal circadian clock via PI3K/AKT pathway, exacerbating Alzheimer-like

Chunmei Huang1, Qin Cai1, Zeru Feng1

  • 1Department of Geriatric Dentistry, State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|June 10, 2026
PubMed
Abstract

Keywords:
Alzheimer's diseasePI3K/AKT signaling pathwayastrocyte activationcircadian clockmicroglial activationneuroinflammationperiodontitis

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