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Related Concept Videos

Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.

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Related Experiment Video

Updated: Jun 12, 2026

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
08:48

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Published on: November 22, 2019

Real-time mode-modulation enhanced stable imaging through flexible multimode fiber.

Ning Zhan, Zhenming Yu, Liming Cheng

    Optics Express
    |June 11, 2026
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a new method to stabilize flexible multimode fibers (MMFs) for high-resolution medical imaging. The technique rapidly calibrates fiber bending, enabling clear, real-time endoscopic visualization in dynamic environments.

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    Last Updated: Jun 12, 2026

    Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
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    Area of Science:

    • Biomedical Optics
    • Fiber Optics
    • Medical Imaging Technology

    Background:

    • Multimode fibers (MMFs) offer potential for ultra-thin, high-resolution endoscopes but suffer from dynamic instability and limited transmission.
    • Clinical application of MMFs is hindered by their susceptibility to bending-induced distortions and performance degradation.

    Purpose of the Study:

    • To develop a method for stable, high-fidelity, real-time imaging through flexible, ultra-thin MMFs.
    • To overcome dynamic instability and performance limitations of MMFs for minimally invasive endoscopy.

    Main Methods:

    • A rapid calibration routine (approx. 75 ms) identifies the MMF's bending state using focusing wavefront probes.
    • A pre-calculated database provides a corresponding singular vector for mode modulation.
    • Synchronous retrieval and projection of the singular vector excite intrinsic fiber modes for enhanced transmission.

    Main Results:

    • Substantial improvements in image fidelity were achieved in dynamically flexing 40-µm and 105-µm-core MMFs.
    • Peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) improved by up to 7.75 dB and 0.069 for digits.
    • Edge preservation index increased by 12.10% for biological specimen imaging.

    Conclusions:

    • The proposed method effectively stabilizes MMFs, overcoming the trade-off between miniaturization and image quality.
    • This technique provides a robust, fast solution, removing a critical barrier for MMF-based imaging.
    • Enables a practical pathway for deploying high-resolution, hair-thin fiber endoscopes in clinical settings.