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Related Experiment Video

Updated: Jun 12, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

Time-domain optical coherence tomography at 2 µm using GaSb-based broadband superluminescent diode.

Ifte Khairul Alam Bhuiyan, Alejandro Martínez Jiménez, Ramona Cernat

    Optics Express
    |June 11, 2026
    PubMed
    Summary

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    Total Internal Reflection Fluorescence Microscopy01:05

    Total Internal Reflection Fluorescence Microscopy

    Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.

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    Applied optics·2025

    We developed a compact time-domain optical coherence tomography (TD-OCT) system using a Gallium Antimonide-based superluminescent diode (GaSb-SLD). This novel GaSb-SLD source enables practical mid-infrared OCT imaging for non-biological materials.

    Area of Science:

    • Optics and Photonics
    • Materials Science
    • Biomedical Engineering

    Background:

    • Time-domain optical coherence tomography (TD-OCT) is a valuable imaging technique.
    • Existing 2 µm OCT systems often rely on complex supercontinuum sources.
    • There is a need for compact and practical light sources for mid-infrared OCT.

    Purpose of the Study:

    • To demonstrate a novel TD-OCT system operating in the 2 µm spectral region.
    • To utilize a Gallium Antimonide-based superluminescent diode (GaSb-SLD) as the light source.
    • To assess the feasibility of GaSb-SLD for compact mid-infrared OCT instrumentation.

    Main Methods:

    • Developed a TD-OCT system centered at 2.1 µm using a GaSb-based SLD.
    • The SLD provided a spectral width of ~80 nm with low ripple (<20%) at drive currents <150 mA.

    Related Experiment Videos

    Last Updated: Jun 12, 2026

    Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
    12:54

    Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

    Published on: October 2, 2021

  • Integrated the fiber-coupled SLD into a fiber-based Michelson interferometer for OCT imaging.

    • Main Results:

    • Achieved an axial resolution of approximately 300 µm in air.
    • Successfully performed depth-resolved imaging of scattering paint-based coating samples.
    • Demonstrated stable amplified spontaneous emission from the GaSb-SLD for OCT operation.

    Conclusions:

    • The GaSb-SLD offers a compact, practical, and scalable alternative to supercontinuum sources for 2 µm OCT.
    • This study represents the first demonstration of TD-OCT imaging at 2 µm using a GaSb-SLD.
    • The developed system is suitable for mid-infrared OCT instrumentation targeting non-biological, low-water-content materials.