Related Experiment Video
Updated: Jun 12, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Patient Perspectives, Unmet Needs and Dilemmas in Reproductive Decision-making for Genodermatoses: A Qualitative
Fauve C A P Van Veen1, Otte J M Borghouts2, Julia M K Clabbers2
1Department of Dermatology, Maastricht UMC+ Centre of Expertise for Genodermatoses, University of Maastricht, Maastricht University Medical Centre+, Maastricht, Netherlands; GROW school for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands. fauve.van.veen@mumc.nl.
Individuals with inherited skin diseases (genodermatoses) face complex reproductive decisions. Many prioritize avoiding passing on the condition, highlighting the need for genetic counseling.
Area of Science:
- Medical Genetics
- Dermatology
- Reproductive Health
Background:
- Inherited skin diseases (genodermatoses) significantly impact quality of life.
- Reproductive decision-making (RDM) in affected individuals is poorly understood.
- Genodermatoses can create dilemmas for those considering parenthood.
Purpose of the Study:
- To explore the perspectives of individuals with genodermatoses on RDM.
- To understand the impact of genodermatoses on the desire for children.
- To assess knowledge and experiences with reproductive options and counseling.
Main Methods:
- Qualitative study using semi-structured interviews.
- Participants: individuals aged ≥16 with genodermatoses and desire for children.
- Analysis: reflexive thematic content approach.
Main Results:
- Participants prioritized avoiding transmission of genodermatoses to offspring.
- Fear and uncertainty about disease severity in children influenced decisions.
- Lack of routine reproductive counseling identified as a clinical gap.
Conclusions:
- Genodermatoses profoundly affect reproductive decision-making.
- There is a critical need for integrated reproductive counseling in genodermatosis care.
- Addressing patient concerns about disease transmission is essential.
Related Concept Videos
Pharmacogenomics: Identification of New Drug Targets
Pedigree Analysis
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics and Pharmacogenomics: Overview
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
