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Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

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Updated: Jun 12, 2026

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
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Femtosecond-Laser-Induced Physical Unclonable Random Maze Structure for Storage-Free Encryption.

Shiru Jiang1,2,3, Hongliang Li4, Shengjie Ma2

  • 1State Key Laboratory of Precision Spectroscopy, Hainan Institute, East China Normal University, Shanghai, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 11, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces novel gold maze physical unclonable functions (PUFs) for secure, storage-free encryption. These PUFs offer accessible hardware security without needing to store responses or keys.

Keywords:
femtosecond lasergold random maze structuremarangoni convectionon‐site generated keyphysical unclonable functions

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Area of Science:

  • Materials Science
  • Cryptography
  • Nanotechnology

Background:

  • Physical unclonable functions (PUFs) offer hardware-level security but face challenges with response accessibility and storage.
  • Existing PUF designs often require significant storage for responses and keys, limiting their application in miniaturized devices.

Purpose of the Study:

  • To develop a novel, multi-level, and easily accessible PUF system for secure information encryption.
  • To demonstrate a storage-free encryption process using PUFs based on gold random maze structures.

Main Methods:

  • Fabrication of gold random maze structures using femtosecond-laser-induced plasmonic effects and Marangoni convection.
  • Development of independent optical and electrical PUFs leveraging the random morphologies of the gold mazes.
  • On-site acquisition of PUF responses and real-time key generation for encryption on an integrated circuit platform.

Main Results:

  • Successful creation of independent optical and electrical PUFs based on gold random mazes.
  • Demonstration of on-site response acquisition and real-time key generation, enabling secure, storage-free encryption.
  • Validation of a high-security encryption process on an integrated circuit, showcasing next-generation security architectures.

Conclusions:

  • The proposed gold maze PUFs provide a secure and efficient solution for hardware-level information protection.
  • This approach eliminates the need for storing PUF responses and cryptographic keys, paving the way for advanced, on-site security systems.
  • The study highlights a significant shift towards next-generation security architectures that rely on real-time key generation and integrated PUF functionalities.