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Updated: Jun 12, 2026

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
07:31

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Published on: February 17, 2023

Synergistic HMGN1 and VP64 Fusions Potentiate High-Precision and PAM-Flexible Base Editing

Xi Luo1,2, Yuyao Qu1,2, Zhengyan Ye1,2

  • 1State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Collaborative Innovation Center for Modern Crop Production co-sponsored by Province and Ministry, Nanjing Agricultural University, Nanjing, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 11, 2026
PubMed
Summary

Researchers developed new base editors (BEs) using SpRY and cytidine deaminases, enhanced by HMGN1 and VP64. This advanced genome editing technology achieves high precision and efficiency across various organisms.

Keywords:
CRISPRHMGN1SpRYVP64base editingbiotechnologycytidine deaminasegene therapygenome editingprecise editing

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