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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Structure-Activity Relationships and Drug Design01:28

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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...

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Updated: Jun 12, 2026

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI-Oriented Perspective.

Dominika Wilczok1,2, Jesús Valdés-Hernández3, Varinia Bernales3,4,5

  • 1Duke University, Durham, North Carolina, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 11, 2026
PubMed
Summary
This summary is machine-generated.

Developing new cryoprotective agents (CPAs) requires balancing multiple factors, similar to drug discovery. This multiparameter optimization approach aims to create safer, more effective CPAs for advanced cryopreservation applications.

Keywords:
AI‐assisted molecular designartificial intelligencecryoprotective agentsengineered cryoprotective materialsmultiparameter optimization

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Do-It-Yourself Device for Recovery of Cryopreserved Samples Accidentally Dropped into Cryogenic Storage Tanks
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Published on: May 11, 2012

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Last Updated: Jun 12, 2026

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

Do-It-Yourself Device for Recovery of Cryopreserved Samples Accidentally Dropped into Cryogenic Storage Tanks
05:47

Do-It-Yourself Device for Recovery of Cryopreserved Samples Accidentally Dropped into Cryogenic Storage Tanks

Published on: May 11, 2012

Area of Science:

  • Biotechnology
  • Cryobiology
  • Biomedical Engineering

Background:

  • Cryopreservation is crucial for biobanking, reproductive medicine, and transplantation.
  • Current cryoprotective agents (CPAs) face limitations, including toxicity at high concentrations needed for vitrification.
  • Advancements in preserving sensitive cells, organs, and organisms necessitate improved CPAs.

Purpose of the Study:

  • To apply principles from drug discovery to the design of next-generation cryoprotective agents.
  • To address the need for CPAs with improved safety and efficacy profiles.
  • To frame cryoprotectant development as a multiparameter optimization challenge.

Main Methods:

  • Drawing parallels between drug lead optimization and cryoprotectant development.
  • Applying multiparameter optimization strategies to CPA design.
  • Analyzing the requirements for ideal cryoprotectants.

Main Results:

  • The study proposes a novel framework for CPA development inspired by drug discovery.
  • It highlights the necessity of balancing multiple criteria for effective cryoprotectants.
  • It suggests that a systematic, multiparameter approach can lead to improved CPAs.

Conclusions:

  • Treating cryoprotectant development as a multiparameter optimization challenge, akin to drug lead optimization, is a promising strategy.
  • This approach can facilitate the systematic design of safer and more effective CPAs.
  • This perspective is vital for advancing cryopreservation technologies for complex biological materials.