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Related Experiment Video

Updated: Jun 12, 2026

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

Clinical fluorescent contrast agents for image-guided surgery.

Jingyao Wang^1,2, Yu-Si Liao¹, Jian-Xiao Liang^1,2

¹CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China.

Fundamental Research

|June 11, 2026

Summary

This summary is machine-generated.

Fluorescence image-guided surgery (FIGS) uses advanced contrast agents for better surgical precision. FDA-approved agents and emerging molecular probes enhance tumor visualization and patient outcomes.

Keywords:

Fluorescent contrast agents Imaging Near-infrared Surgery Tumor

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Last Updated: Jun 12, 2026

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

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Published on: October 20, 2010

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Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

Area of Science:

Surgical Oncology
Medical Imaging
Pharmacology

Background:

Fluorescence image-guided surgery (FIGS) enhances intraoperative visualization.
Precision surgery demands contrast agents with improved specificity, safety, and efficacy.
Regulatory approvals mark significant progress in FIGS contrast agents.

Purpose of the Study:

To review FDA-approved intraoperative fluorescence contrast agents.
To summarize emerging agents in clinical evaluation.
To discuss agent selection criteria and future directions in precision surgery.

Main Methods:

Comprehensive review of seven FDA-approved agents (ICG, Fluorescein Sodium, 5-ALA, MB, Cysview, Cytalux, Akalux).
Analysis of molecular characteristics, indications, and clinical performance.
Summary of emerging targeted molecular probes.

Main Results:

FDA-approved agents include ICG, Fluorescein Sodium, 5-ALA, MB, Cysview, Cytalux, and Akalux.
Emerging agents show a trend towards targeted molecular probes.
Targeted agents improve tumor visualization, margin delineation, and detection of occult lesions, leading to better resections.

Conclusions:

The evolution of contrast agents supports precision medicine in surgery.
Appropriate agent selection depends on tissue specificity, administration, imaging depth, and regulatory status.
Integration of molecular diagnostics and imaging will drive individualized surgical interventions and theranostics.