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Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Bone Markings01:26

Bone Markings

Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Gross Anatomy of Bone01:17

Gross Anatomy of Bone

The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...

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Related Experiment Video

Updated: Jun 12, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
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Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Crosstalk between bone and vasculature within bone.

Wenyu Xia1, Wei Wang1,2, Yi Qin1

  • 1Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Fundamental Research
|June 11, 2026
PubMed
Summary
This summary is machine-generated.

The bone and vascular systems are intricately linked, influencing bone health and disease. Understanding this skeletal-vasculature axis offers new therapeutic approaches for bone disorders.

Keywords:
AngiogenesisBlood vesselsBone remodelingLymphatic VesselsVasculature

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Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
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Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
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Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

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Related Experiment Videos

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Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Area of Science:

  • Skeletal Biology
  • Vascular Biology
  • Connective Tissue Research

Background:

  • Bone physiology and pathology are closely tied to the vascular system, encompassing both blood and lymphatic vessels.
  • Previous reviews have predominantly focused on the relationship between bone and blood vessels, neglecting the lymphatic system's role.
  • Vascular vessels within bone form a crucial component of the bone microenvironment, interacting with bone structure.

Purpose of the Study:

  • To highlight the comprehensive role of the entire vasculature, including lymphatic vessels, in bone physiology and pathology.
  • To emphasize the bidirectional communication and signaling crosstalk between the skeletal and vascular systems.
  • To explore the therapeutic potential of targeting the skeletal-vasculature axis for bone-related diseases.

Main Methods:

  • Literature review and synthesis of existing research on bone-vasculature interactions.
  • Analysis of the paracrine functions of vasculature in bone development, homeostasis, and remodeling.
  • Examination of osteolineage cell regulation of vascular system activity.

Main Results:

  • The paracrine function of vasculature is vital for bone development, homeostasis, regeneration, modeling, and remodeling.
  • Osteolineage cells actively regulate the physiological activity of the vascular system.
  • Complex signaling crosstalk between bone and vascular systems coordinates bone formation and resorption.

Conclusions:

  • The skeletal-vasculature axis is a critical determinant of bone health and disease.
  • Targeting this axis presents novel therapeutic strategies for skeletal and vascular-related pathologies.
  • A comprehensive understanding of both blood and lymphatic systems in bone is essential.