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Updated: Jun 12, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Published on: November 5, 2019

Case Report: Cutaneous niche-restricted malignant phenotypes in PTCL-NOS revealed by single-cell sequencing.

Shucheng Zhang1,2,3, Zhuqing Li1,2,3, Yang Lin1,2,3

  • 1Department of Dermatology, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.

Frontiers in Oncology
|June 11, 2026
PubMed
Summary

Disseminated cutaneous Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) shows distinct molecular profiles in skin versus blood. Understanding these differences is key for developing targeted therapies for aggressive T-cell lymphomas.

Keywords:
NF-κB signalingPTCL-NOScutaneous lymphomametabolic reprogrammingsingle-cell RNA sequencingtreatment resistancetumor microenvironment

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