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Updated: Jun 12, 2026
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
The CKD-OSTEO Score: A Chronic Kidney Disease-specific Tool for Osteoporosis Risk Stratification
Sourabh Sharma1, Sanjay Kalra2,3, Nitin Kapoor4,5
1Department of Nephrology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Touchreviews in Endocrinology
|June 11, 2026
Summary
Osteoporosis in chronic kidney disease (CKD) patients is often missed. The new CKD-OSTEO score helps identify osteoporosis risk, guiding diagnosis and treatment for better fracture prevention.
Area of Science:
- Nephrology
- Endocrinology
- Geriatrics
Background:
- Osteoporosis in chronic kidney disease (CKD) is underdiagnosed and undertreated.
- Standard osteoporosis tools are inadequate for CKD patients due to unique bone alterations.
- CKD involves complex pathophysiology affecting bone health.
Purpose of the Study:
- Introduce the Chronic Kidney Disease Osteoporosis Stratification Tool for Evaluation and Optimization (CKD-OSTEO) score.
- Provide a multidimensional tool for osteoporosis risk assessment in CKD.
- Guide diagnostic assessments and inform treatment strategies for CKD patients.
Main Methods:
- Developed the CKD-OSTEO score integrating conventional and CKD-specific factors.
- Included factors like dialysis vintage, parathormone, Klotho levels, and T-scores.
- Categorized patients into management levels with tailored anti-resorptive therapy recommendations.
Main Results:
- The CKD-OSTEO score offers a novel approach to CKD osteoporosis risk stratification.
- Identified Klotho deficiency as a significant marker of bone-vascular aging.
- Established a framework for customized management and treatment selection.
Conclusions:
- Regular risk stratification using tools like CKD-OSTEO is crucial for CKD patients.
- The score aims to enhance fracture prevention and optimize therapeutic interventions.
- Advocates for incorporating novel biomarkers like Klotho into clinical practice.
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