Related Experiment Video

Updated: Jun 12, 2026

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
09:57

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Published on: January 20, 2022

Cardiac computed tomography-derived left atrial volume index as a predictor of major adverse cardiovascular events

Jiaming Li1, Jun Shu1, Jin Zhang1

  • 1Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Quantitative Imaging in Medicine and Surgery
|June 11, 2026
PubMed

Insights

Elevated left atrial volume index (LAVI) measured by coronary computed tomography angiography (CCTA) predicts major adverse cardiovascular events (MACE) after transcatheter aortic valve replacement (TAVR) in severe aortic stenosis (AS). This finding aids in post-TAVR risk stratification.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Left atrial volume index (LAVI) is a key indicator of left heart remodeling and diastolic dysfunction.
  • Severe aortic stenosis (AS) necessitates interventions like transcatheter aortic valve replacement (TAVR).
  • Assessing pre-TAVR risk factors for adverse outcomes is crucial.

Purpose of the Study:

  • To investigate the association between LAVI, assessed via CCTA, and major adverse cardiovascular events (MACE) in severe AS patients post-TAVR.
  • To determine if CCTA-derived LAVI can predict MACE in this patient cohort.
  • To explore the relationship between LAVI and MACE in patients undergoing TAVR.

Main Methods:

  • Retrospective single-center study of 206 severe AS patients undergoing TAVR.
  • Pre-TAVR CCTA was used for automatic left atrial (LA) volume quantification and LAVI calculation.
  • Univariate, Firth-penalized Cox regression, and restricted cubic spline analyses were employed to identify MACE predictors.

Main Results:

  • MACE occurred in 13.1% of patients during a median follow-up of 581 days.
  • Patients with MACE had significantly higher LAVI compared to those without (70.14 vs. 51.19 mL/m², P<0.001).
  • Adjusted analysis revealed LAVI ≥53.32 mL/m² (HR=4.249) and male sex (HR=2.864) independently predicted MACE, with a nonlinear relationship observed between LAVI and MACE (P=0.032).

Conclusions:

  • Preprocedural CCTA-derived LAVI is a valuable tool for stratifying MACE risk in severe AS patients after TAVR.
  • Elevated LAVI identifies patients at higher risk for adverse cardiovascular events post-TAVR.
  • Male patients may require closer postprocedural monitoring.
Abstract

Keywords:
Severe aortic stenosis (severe AS)left atrial volume index (LAVI)major adverse cardiovascular events (MACEs)transcatheter aortic valve replacement (TAVR)

More Related Videos

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

Related Concept Videos

Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...